Kratom, a herbal substance derived from the Mitragyna speciosa tree native to Southeast Asia, has stirred headlines in recent months. At the heart of the conversation is 7-Hydroxymitragynine (7-OH)—one of its most potent psychoactive compounds. With increasing emergency room visits and debates over legality and safety, Zoe Psychiatry takes a closer look at what Kratom and 7-OH really are, how they affect the body, and what you should do if you’re concerned.

What Is Kratom?

Kratom leaves have traditionally been used for their stimulant and pain-relieving properties. In small doses, users may experience increased energy and alertness. At higher doses, Kratom acts more like an opioid, producing euphoria, sedation, and even dependency.

To start your recovery from Kratom addiction, call Dr. Popoola’s clinic at 972 521–6191

The Role of 7-Hydroxymitragynine (7-OH)

Need help understanding your options? Dr. Popoola and the team at Zoe Psychiatry are here to guide you.

While Kratom contains multiple alkaloids, 7-Hydroxymitragynine is considered one of the most powerful. Despite being present in smaller quantities than mitragynine (Kratom’s primary compound), 7-OH is significantly more potent—some sources say up to 13 times stronger than morphine by weight in terms of analgesic effect.

7-OH is not just naturally occurring—it also forms in the body when mitragynine is metabolized by the liver. That makes it central to understanding Kratom’s opioid-like effects and its potential for abuse, dependency, and overdose.

If you feel symptoms, don’t wait until they escalate. Call Zoe Psychiatry today or book an online appointment and speak with a specialist 

Why Is Kratom and 7-OH Making Headlines

In 2025, several states in the U.S. have proposed stricter regulations or outright bans on Kratom due to increasing reports of:
– Opioid-like overdoses
– Psychiatric side effects (agitation, hallucinations)
– Withdrawal symptoms
– Product contamination with fentanyl or heavy metals

Many of these issues are directly tied to high-potency derivatives like 7-Hydroxymitragynine, or synthetic formulations mimicking it.

Early intervention is key. Reach out to Zoe Psychiatry for help with Kratom-related issues.

Is Kratom Legal?

The legal status of Kratom varies by country and U.S. state. While the FDA has not approved Kratom for any medical use, it’s still widely available online and in smoke shops.

However, the DEA has considered classifying Kratom’s active compounds—including 7-OH—as Schedule I drugs, citing risks similar to heroin or fentanyl. Meanwhile, some people use Kratom to self-manage pain, opioid withdrawal, or anxiety, despite the lack of clinical safety data.

Need help understanding your options? Dr. Popoola is an addiction medicine expert who is double board-certified. Click here to schedule an appointment..

Is Kratom Addictive?

Yes—especially because of 7-Hydroxymitragynine. Its opioid receptor activity can lead to:
– Tolerance (needing more over time)
– Dependence (requiring it to feel normal)
– Withdrawal (flu-like symptoms, insomnia, depression)

Users often don’t realize how quickly dependence can form, especially when using high doses or potent extracts.

What Does Zoe Psychiatry Recommend?

If you or a loved one is using Kratom or experiencing withdrawal, you’re not alone—and help is available.

Zoe Psychiatry offers compassionate, science-backed care for individuals facing substance misuse, including Kratom and opioid-like compounds. We provide:
– Medical detox and supervision
– Psychological support and behavioral therapy
– Holistic, non-judgmental approaches to healing

Final Thoughts

While Kratom may appear “natural” and legal, compounds like 7-Hydroxymitragynine show that “natural” doesn’t always mean safe. As Kratom becomes more potent and widely available, understanding the risks—and getting help early—can save lives.

Need Support Now?

Call or book an appointment with Zoe Psychiatry today for guidance, support, and treatment options tailored to you. Remember, we listen and help, and we don’t judge. Also don’t forget to check out our other highly educative blogs!